In diesem Abschnitt werden die Veröffentlichungen zur Forschung im Rahmen von NCER-PD aufgeführt, wie beispielweise Ergebnisse aus der Luxemburger Parkinson-Studie. Sie können die folgende Liste nach Jahr sortiert durchsuchen. Für einige Veröffentlichungen haben wir bereits eine Zusammenfassung in Englisch, Deutsch und Französisch zur Verfügung gestellt.


Bowring, F., Welch, J., Woodward, C., Lo, C., Lawton, M., Sulzer, P., Hanff, A.-M., Kruger, R., Liepelt-Scarfone, I., & Hu, M. T. (2022). Exploration of whether socioeconomic factors affect the results of priority setting partnerships: updating the top 10 research priorities for the management of Parkinson’s in an international setting. BMJ Open12(6), e049530.

Domenighetti, C., Sugier, P., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., Portugal, B., May, P., Bobbili, D. R., Radivojkov‐Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A. E., … the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage‐PD) Consortium. (2022). Dairy Intake and Parkinson’s Disease: A Mendelian Randomization Study. Movement Disorders, mds.28902.

Koko, M., Motelow, J. E., Stanley, K. E., Bobbili, D. R., Dhindsa, R. S., May, P., Canadian Epilepsy Network, Epi4K Consortium, Epilepsy Phenome/Genome Project, EpiPGX Consortium, EuroEPINOMICS‐CoGIE Consortium, Alldredge, B. K., Allen, A. S., Altmüller, J., Amrom, D., Andermann, E., Auce, P., Avbersek, A., Baulac, S., … Zimprich, F. (2022). Association of ultra‐rare coding variants with genetic generalized epilepsy: A case–control whole exome sequencing study. Epilepsia, epi.17166.

on behalf of the Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium, Domenighetti, C., Sugier, P.-E., Sreelatha, A. A. K., Schulte, C., Grover, S., Mohamed, O., Portugal, B., May, P., Bobbili, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., … Elbaz, A. (2022). Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson’s Disease. Journal of Parkinson’s Disease12(1), 267–282.

on behalf of the NCER-PD Consortium, Hanff, A.-M., Leist, A. K., Fritz, J. V., Pauly, C., Krüger, R., & Halek, M. (2022). Determinants of Self-Stigma in People with Parkinson’s Disease: A Mixed Methods Scoping Review. Journal of Parkinson’s Disease12(2), 509–522.

Schmitz, S., Vaillant, M., Renoux, C., Konsbruck, R. L., Hertz, P., Perquin, M., Pavelka, L., Krüger, R., & Huiart, L. (2022). Prevalence and Cost of Care for Parkinson’s Disease in Luxembourg: An Analysis of National Healthcare Insurance Data. PharmacoEconomics - Open.

Vega, C., Gawron, P., Lebioda, J., Grouès, V., Matyjaszczyk, P., Pauly, C., Smula, E., Krüger, R., Schneider, R., & Satagopam, V. (2022). Smart Scheduling (SMASCH): multi-appointment scheduling system for longitudinal clinical research studies. JAMIA Open5(2), ooac038.

Zagare, A., Barmpa, K., Smajic, S., Smits, L. M., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S. L., & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. The American Journal of Human Genetics109(2), 311–327.


Badanjak, K., Mulica, P., Smajic, S., Delcambre, S., Tranchevent, L.-C., Diederich, N., Rauen, T., Schwamborn, J. C., Glaab, E., Cowley, S. A., Antony, P. M. A., Pereira, S. L., Venegas, C., & Grünewald, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease. Frontiers in Cell and Developmental Biology9, 740758.

Barbuti, P. A., Ohnmacht, J., Santos, B. F. R., Antony, P. M., Massart, F., Cruciani, G., Dording, C. M., Pavelka, L., Casadei, N., Kwon, Y.-J., & Krüger, R. (2021). Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function. Scientific Reports11(1), 21946.

Becker, S., Pauly, C., Lawton, M., Hipp, G., Bowring, F., Sulzer, P., Hu, M., Krüger, R., Gasser, T., & Liepelt-Scarfone, I. (2021). Quantifying activities of daily living impairment in Parkinson’s disease using the Functional Activities Questionnaire. Neurological Sciences.

Brown, S. J., Boussaad, I., Jarazo, J., Fitzgerald, J. C., Antony, P., Keatinge, M., Blechman, J., Schwamborn, J. C., Krüger, R., Placzek, M., & Bandmann, O. (2021). PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Scientific Reports11(1), 6617.

Chia, Ruth, R., Sabir, M. S., Bandres-Ciga, S., Saez-Atienzar, S., Reynolds, R. H., Gustavsson, E., Walton, R. L., Ahmed, S., Viollet, C., Ding, J., Makarious, M. B., Diez-Fairen, M., Portley, M. K., Shah, Z., Abramzon, Y., Hernandez, D. G., Blauwendraat, C., Stone, D. J., Eicher, J., … Scholz, S. W. (2021). Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics53(3), 294–303.

Giovagnoni, C., Ali, M., Eijssen, L. M. T., Maes, R., Choe, K., Mulder, M., Kleinjans, J., del Sol, A., Glaab, E., Mastroeni, D., Delvaux, E., Coleman, P., Losen, M., Pishva, E., Martinez-Martinez, P., & van den Hove, D. L. A. (2021). Altered sphingolipid function in Alzheimer’s disease; a gene regulatory network approach. Neurobiology of Aging102, 178–187.

Glaab, E., Rauschenberger, A., Banzi, R., Gerardi, C., Garcia, P., & Demotes, J. (2021). Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review. BMJ Open11(12), e053674.

Grover, S., Kumar‐Sreelatha, A. A., Bobbili, D. R., May, P., Domenighetti, C., Sugier, P., Schulte, C., COURAGE‐PD Consortium, Elbaz, A., Krüger, R., Gasser, T., Sharma, M., & COURAGE‐PD Consortium. (2021). Replication of a Novel Parkinson’s Locus in a European Ancestry Population. Movement Disorders36(7), 1689–1695.

Hanff, A.-M., Pauly, C., Pauly, L., Schröder, V. E., Hansen, M., Meyers, G. R., Kaysen, A., Hansen, L., Wauters, F., & Krüger, R. (2021). Unmet Needs of People With Parkinson’s Disease and Their Caregivers During COVID-19-Related Confinement: An Explorative Secondary Data Analysis. Frontiers in Neurology11, 615172.

Hassanin, E., May, P., Aldisi, R., Spier, I., Forstner, A. J., Nöthen, M. M., Aretz, S., Krawitz, P., Bobbili, D. R., & Maj, C. (2021a). Breast and prostate cancer risk: The interplay of polygenic risk, rare pathogenic germline variants, and family history. Genetics in Medicine, S1098360021053879.

Imm, J., Pishva, E., Ali, M., Kerrigan, T. L., Jeffries, A., Burrage, J., Glaab, E., Cope, E. L., Jones, K. M., Allen, N. D., & Lunnon, K. (2021). Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation. Frontiers in Cell and Developmental Biology9, 647981.

Kaczmarek, A. T., Bahlmann, N., Thaqi, B., May, P., & Schwarz, G. (2021). Machine learning-based identification and characterization of 15 novel pathogenic SUOX missense mutations. Molecular Genetics and Metabolism134(1–2), 188–194.

Kaivola, K., Shah, Z., Chia, R., International LBD Genomics Consortium, & Scholz, S. W. (2021). Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain, awab402.
Hassanin, E., May, P., Aldisi, R., Krawitz, P., Maj, C., & Bobbili, D. R. (2021). Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson’s disease [Preprint]. Genetic and Genomic Medicine.

Kern, F., Fehlmann, T., Violich, I., Alsop, E., Hutchins, E., Kahraman, M., Grammes, N. L., Guimarães, P., Backes, C., Poston, K. L., Casey, B., Balling, R., Geffers, L., Krüger, R., Galasko, D., Mollenhauer, B., Meese, E., Wyss-Coray, T., Craig, D. W., … Keller, A. (2021). Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression. Nature Aging1(3), 309–322.

Koko, M., Krause, R., Sander, T., Bobbili, D. R., Nothnagel, M., May, P., Lerche, H., Feng, Y.-C. A., Howrigan, D. P., Abbott, L. E., Tashman, K., Cerrato, F., Singh, T., Heyne, H., Byrnes, A., Churchhouse, C., Watts, N., Solomonson, M., Lal, D., … Neale, B. M. (2021). Distinct gene-set burden patterns underlie common generalized and focal epilepsies. EBioMedicine72, 103588.

Mencke, P., Boussaad, I., Romano, C. D., Kitami, T., Linster, C. L., & Krüger, R. (2021). The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease. Cells10(2), 347.

Rauschenberger, A., & Glaab, E. (2021). Predicting correlated outcomes from molecular data. Bioinformatics37(21), 3889–3895.

Rauschenberger, A., Glaab, E., & van de Wiel, M. A. (2021). Predictive and interpretable models via the stacked elastic net. Bioinformatics37(14), 2012–2016.

Smajić, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (2021). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain, awab446.

The Global Parkinson’s Genetics Program. (2021). GP2: The Global Parkinson’s Genetics Program. Movement Disorders36(4), 842–851.

the Parkinson’s Disease Digital Biomarker Challenge Consortium, Sieberts, S. K., Schaff, J., Duda, M., Pataki, B. Á., Sun, M., Snyder, P., Daneault, J.-F., Parisi, F., Costante, G., Rubin, U., Banda, P., Chae, Y., Chaibub Neto, E., Dorsey, E. R., Aydın, Z., Chen, A., Elo, L. L., Espino, C., … Omberg, L. (2021). Crowdsourcing digital health measures to predict Parkinson’s disease severity: the Parkinson’s Disease Digital Biomarker DREAM Challenge. Npj Digital Medicine4(1), 53.

van Rumund, A., Pavelka, L., Esselink, R. A. J., Geurtz, B. P. M., Wevers, R. A., Mollenhauer, B., Krüger, R., Bloem, B. R., & Verbeek, M. M. (2021). Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase. Npj Parkinson’s Disease7(1), 29.


Antony, P.M.A., Kondratyeva, O., Mommaerts, K. et al. (2020) Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization. Sci Rep, 10, 1569.

Baldini, F., Hertel, J., Sandt, E., Thinnes, C. C., Neuberger-Castillo, L., Pavelka, L., Betsou, F., Krüger, R., & Thiele, I. (2020). Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions. BMC Biology, 18(1), 62. >> Lesen Sie die Zusammenfassung

Barbe, M. T., Tonder, L., Krack, P., Debû, B., Schüpbach, M., Paschen, S., Dembek, T. A., Kühn, A. A., Fraix, V., Brefel-Courbon, C., Wojtecki, L., Maltête, D., Damier, P., Sixel-Döring, F., Weiss, D., Pinsker, M., Witjas, T., Thobois, S., Schade-Brittinger, C., Rau, J., … EARLYSTIM study group (2020). Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor Complications. Movement disorders : official journal of the Movement Disorder Society, 35(1), pp 82–90.

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease. Human molecular genetics, 29(8), 1353–1364.

Bobbili, D.R., Banda, P., Krüger, R., May, P. (2020) Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk. Journal of Medical Genetics, 57(9), pp 617-623.

Boussaad, I., Obermaier, C. D., Hanss, Z., Bobbili, D. R., Bolognin, S., Glaab, E., Wołyńska, K., Weisschuh, N., De Conti, L., May, C., Giesert, F., Grossmann, D., Lambert, A., Kirchen, S., Biryukov, M., Burbulla, L. F., Massart, F., Bohler, J., Cruciani, G., Schmid, B., … Krüger, R. (2020). A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Science translational medicine, 12(560), eaau3960. >> Lesen Sie die Zusammenfassung

EuroEPINOMICS-RES Consortium, Lal, D., May, P., Perez-Palma, E., Samocha, K. E., Kosmicki, J. A., Robinson, E. B., Møller, R. S., Krause, R., Nürnberg, P., Weckhuysen, S., De Jonghe, P., Guerrini, R., Niestroj, L. M., Du, J., Marini, C., Ware, J. S., Kurki, M., Gormley, P., … Daly, M. J. (2020). Gene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders. Genome Medicine12(1), 28.

Fehlmann, T., Kahraman, M., Ludwig, N., Backes, C., Galata, V., Keller, V., Geffers, L., Mercaldo, N., Hornung, D., Weis, T., Kayvanpour, E., Abu-Halima, M., Deuschle, C., Schulte, C., Suenkel, U., von Thaler, A.-K., Maetzler, W., Herr, C., Fähndrich, S., … Keller, A. (2020). Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA Oncology6(5), 714.

Hanss, Z., Boussaad, I., Jarazo, J., Schwamborn, J. C., & Krüger, R. (2020). Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a PseudogeneFrontiers in genetics, 10, 1297.

Hendrickx, D. M., & Glaab, E. (2020). Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes. BMC Medical Genomics13(1), 114.

Heyne, H. O., Baez-Nieto, D., Iqbal, S., Palmer, D. S., Brunklaus, A., May, P., Epi25 Collaborative, Johannesen, K. M., Lauxmann, S., Lemke, J. R., Møller, R. S., Pérez-Palma, E., Scholl, U. I., Syrbe, S., Lerche, H., Lal, D., Campbell, A. J., Wang, H.-R., Pan, J., & Daly, M. J. (2020). Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Science Translational Medicine12(556), eaay6848.

Iqbal, S., Hoksza, D., Pérez-Palma, E., May, P., Jespersen, J. B., Ahmed, S. S., Rifat, Z. T., Heyne, H. O., Rahman, M. S., Cottrell, J. R., Wagner, F. F., Daly, M. J., Campbell, A. J., & Lal, D. (2020). MISCAST: MIssense variant to protein StruCture Analysis web SuiTe. Nucleic Acids Research48(W1), W132–W139.

Iqbal, S., Pérez-Palma, E., Jespersen, J. B., May, P., Hoksza, D., Heyne, H. O., Ahmed, S. S., Rifat, Z. T., Rahman, M. S., Lage, K., Palotie, A., Cottrell, J. R., Wagner, F. F., Daly, M. J., Campbell, A. J., & Lal, D. (2020). Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants. Proceedings of the National Academy of Sciences117(45), 28201–28211.

Kern, F., Fehlmann, T., Violich, I., Alsop, E., Hutchins, E., Kahraman, M., Grammes, N. L., Guimarães, P., Backes, C., Poston, K., Casey, B., Balling, R., Geffers, L., Krüger, R., Galasko, D., Mollenhauer, B., Meese, E., Wyss-Coray, T., Craig, D. W., … Keller, A. (2020). Deep sncRNA-seq of the PPMI cohort to study Parkinson’s disease progression [Preprint]. Neuroscience.

Larsen, S.B., Hanss, Z., Cruciani, G., Massart, F., Barbuti, P.A., Mellick, G., Krüger, R. (2020) Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35.  Stem Cell Res, 45, 101776.

Monzel, A. S., Hemmer, K., Kaoma, T., Smits, L. M., Bolognin, S., Lucarelli, P., Rosety, I., Zagare, A., Antony, P., Nickels, S. L., Krueger, R., Azuaje, F., & Schwamborn, J. C. (2020). Machine learning-assisted neurotoxicity prediction in human midbrain organoidsParkinsonism & related disorders, 75, 105–109.

Ohnmacht, J., May, P., Sinkkonen, L., & Krüger, R. (2020). Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variationJournal of neural transmission (Vienna, Austria : 1996), 127(5), 729–748.

Rajan, R., Divya, K. P., Kandadai, R. M., Yadav, R., Satagopam, V. P., Madhusoodanan, U. K., Agarwal, P., Kumar, N., Ferreira, T., Kumar, H., Sreeram Prasad, A. V., Shetty, K., Mehta, S., Desai, S., Kumar, S., Prashanth, L. K., Bhatt, M., Wadia, P., Ramalingam, S., … The Lux-GIANT Consortium. (2020). Genetic Architecture of Parkinson’s Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson’s Disease Research. Frontiers in Neurology11, 524.

Schote, A. B., Schiel, F., Schmitt, B., Winnikes, U., Frank, N., Gross, K., Croyé, M.-A., Tarragon, E., Bekhit, A., Bobbili, D. R., May, P., Schick, C., & Meyer, J. (2020). Genome-wide linkage analysis of families with primary hyperhidrosis. PLOS ONE15(12), e0244565.

Stute, L., & Krüger, R. (2020). [Emerging concepts for precision medicine in Parkinson's disease with focus on genetics]Fortschritte Der Neurologie-Psychiatrie.

Vega, C., Grouès, V., Ostaszewski, M., Schneider, R., & Satagopam, V. (2020). BioKC: a collaborative platform for systems biology model curation and annotation [Preprint]. Systems Biology.

Woitalla D, Krüger R, Lorenzl S, et al. (2020) [The role of inhibitors of COMT and MAO-B in the therapy of Parkinson's disease]Fortschritte der Neurologie-psychiatrie.


Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Moreno, E. L., Nickels, S. L., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R., Antony, P., & Schwamborn, J. C. (2018). 3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(1), 1800927.

Glaab, E., Trezzi, J. P., Greuel, A., Jäger, C., Hodak, Z., Drzezga, A., Timmermann, L., Tittgemeyer, M., Diederich, N. J., & Eggers, C. (2019). Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease. Neurobiology of disease, 124, 555–562.

Grossmann, D., Berenguer-Escuder, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Hérouël, A., Sharma, M., Ghelfi, J., Raković, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Grünewald, A., & Krüger, R. (2019). Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease. Antioxidants & redox signaling, 31(16), 1213–1234.

Hertel, J., Harms, A. C., Heinken, A., Baldini, F., Thinnes, C. C., Glaab, E., Vasco, D. A., Pietzner, M., Stewart, I. D., Wareham, N. J., Langenberg, C., Trenkwalder, C., Krüger, R., Hankemeier, T., Fleming, R., Mollenhauer, B., & Thiele, I. (2019). Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease. Cell reports, 29(7), 1767–1777.e8.

Kishore, A., Ashok Kumar Sreelatha, A., Sturm, M., von-Zweydorf, F., Pihlstrøm, L., Raimondi, F., Russell, R., Lichtner, P., Banerjee, M., Krishnan, S., Rajan, R., Puthenveedu, D. K., Chung, S. J., International Parkinson's Disease Genomics Consortium (IPDGC), Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD), Bauer, P., Riess, O., Gloeckner, C. J., Kruger, R., Gasser, T., … Sharma, M. (2019). Understanding the role of genetic variability in LRRK2 in Indian population. Movement disorders : official journal of the Movement Disorder Society, 34(4), 496–505.

Nickels, S.L., Walter, J., Bolognin, S., et al. (2019) Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism Relat. Disord., 67, pp.48–55.

Riederer, P., Berg, D., Casadei, N., Cheng, F., Classen, J., Dresel, C., Jost, W., Krüger, R., Müller, T., Reichmann, H., Rieß, O., Storch, A., Strobel, S., van Eimeren, T., Völker, H. U., Winkler, J., Winklhofer, K. F., Wüllner, U., Zunke, F., & Monoranu, C. M. (2019). α-Synuclein in Parkinson's disease: causal or bystander?. Journal of neural transmission (Vienna, Austria : 1996), 126(7), 815–840.

Schuepbach, W., Tonder, L., Schnitzler, A., Krack, P., Rau, J., Hartmann, A., Hälbig, T. D., Pineau, F., Falk, A., Paschen, L., Paschen, S., Volkmann, J., Dafsari, H. S., Barbe, M. T., Fink, G. R., Kühn, A., Kupsch, A., Schneider, G. H., Seigneuret, E., Fraix, V., … EARLYSTIM study group (2019). Quality of life predicts outcome of deep brain stimulation in early Parkinson disease. Neurology, 92(10), e1109–e1120.

Simons, J. A., Vaillant, M., Hipp, G., Pavelka, L., Stute, L., Pauly, C., & Krüger, R. (2019). Multilingual Validation of the First French Version of Munich Dysphagia Test-Parkinson's Disease (MDT-PD) in the Luxembourg Parkinson's Study. Frontiers in neurology, 10, 1180.

Vollstedt, E. J., Kasten, M., Klein, C., & MJFF Global Genetic Parkinson's Disease Study Group (2019). Using global team science to identify genetic parkinson's disease worldwide. Annals of neurology, 86(2), 153–157.


Blauwendraat, C., Reed, X., Kia, D. A., Gan-Or, Z., Lesage, S., Pihlstrøm, L., Guerreiro, R., Gibbs, J. R., Sabir, M., Ahmed, S., Ding, J., Alcalay, R. N., Hassin-Baer, S., Pittman, A. M., Brooks, J., Edsall, C., Hernandez, D. G., Chung, S. J., Goldwurm, S., Toft, M., … COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease) Consortium, the French Parkinson’s Disease Consortium, and the International Parkinson’s Disease Genomics Consortium (IPDGC) (2018). Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease. JAMA neurology, 75(11), 1416–1422.

Fitzgerald, J.C., Zimprich, A., Reddy Bobbili, D., Sharma, M., May, P., Krüger, R. (2018) Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson's disease. Brain, 141(3), p. e17,

Hipp, G., Vaillant, M., Diederich, N. J., Roomp, K., Satagopam, V. P., Banda, P., Sandt, E., Mommaerts, K., Schmitz, S. K., Longhino, L., Schweicher, A., Hanff, A. M., Nicolai, B., Kolber, P., Reiter, D., Pavelka, L., Binck, S., Pauly, C., Geffers, L., Betsou, F., … Krüger, R. (2018). The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis. Frontiers in aging neuroscience, 10, p 326.

Klucken, J., Krüger, R., Schmidt, P., & Bloem, B. R. (2018). Management of Parkinson's Disease 20 Years from Now: Towards Digital Health Pathways. Journal of Parkinson's disease, 8(s1), S85–S94.

Larsen, S. B., Hanss, Z., & Krüger, R. (2018). The genetic architecture of mitochondrial dysfunction in Parkinson's disease. Cell and tissue research, 373(1), 21–37.

Lhommee, E., Wojtecki, L., Czernecki, V., Witt, K., Maier, F., Tonder, L., Timmermann, L., Halbig, T. D., Pineau, F., Durif, F., Witjas, T., Pinsker, M., Mehdorn, M., Sixel-Doring, F., Kupsch, A., Krüger, R., Elben, S., Chabardes, S., Thobois, S., Brefel-Courbon, C., Ory-Magne, F., Regis, J.-M., Maltete, D., Sauvaget, A., Rau, J., Schnitzler, A., Schupbach, M., Schade-Brittinger, C., Deuschl, G., Houeto, J.-L., & Krack, P. (2018). Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial. Lancet Neurol., 17(3), pp. 223-231. doi: 10.1016/S1474-4422(18)30035-8.

Riederer, P., Jellinger, K. A., Kolber, P., Hipp, G., Sian-Hülsmann, J., & Krüger, R. (2018). Lateralisation in Parkinson disease. Cell and tissue research, 373(1), 297–312.


Antonini, A., Poewe, W., Chaudhuri, K. R., Jech, R., Pickut, B., Pirtošek, Z., Szasz, J., Valldeoriola, F., Winkler, C., Bergmann, L., Yegin, A., Onuk, K., Barch, D., Odin, P., Amalia, E., Arnold, G., Bajenaru, O., Bergmans, B., Bjornara, K. A., ... GLORIA study co-investigators (2017). Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry. Parkinsonism and Related Disorders, 45, pp 13-20.

Ashrafi, A., Garcia, P., Kollmus, H., Schughart, K., del Sol, A., Buttini, M., Glaab, E. (2017) Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease, Neurobiology of Aging, 58, pp. 30, doi: 10.1016/j.neurobiolaging.2017.06.008

Blauwendraat, C., Faghri, F., Pihlstrom, L., Geiger, J. T., Elbaz, A., Lesage, S., May, P., Aude, N., Abramzon, Y., Murphy, N. A., Gibbs, J. R., Ryten, M., Ferrari, R., Bras, J., Guerreiro, R., Williams, J., Sims, R., Lubbe, S., Hernandez, D. G., Mok, K. Y., Robak, L., Camphell, R. H., Rogaeva, E., Traynor, B. J., Chia, R., Chung, S. J., International Parkinson’s Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Glaab, E., Balling, R., Hardy, J. A., Brice, A., Houlden, H., Shulman, J. M., Morris, H. R., Gasser, T., Heutink, P., Krüger, R., Sharma, M., Simon-Sanchez, J., Nalls, M. A., Singleton, A. B., & Scholz, S. W. (2017) NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Neurobiology of Aging, 57, pp 247.e9-247.e13.

Bobbili, D. R., May, P., & Krüger, R. (2017). Rare variant analysis of the PPMI dataset to uncover the complex genetic architecture of Parkinson’s disease. Movement Disorders : Official Journal of the Movement Disorder Society, 322(Supplement S2), 405.

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J., & Krainc, D. (2017). Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease. Science, 357(6357), 1255-1261. >> Lesen Sie die Zusammenfassung

Fitzgerald, J. C., Zimprich, A., Carvajal-Berrio, D. A., Schindler, K. M., Maurer, B., Schulte, C., Bus, C., Hauser, A.-K., Kübler, M., Lewin, R., Bobbili, D. R., Schwarz, L. M., Vartholomaiou, E., Brockmann, K., Wüst, R., Madlung, J., Nordheim, A., Riess, O., Martins, L. M., Glaab, E., May, P., Schenke-Layland, K., Picard, D., Sharma, M., Gasser, T., & Krüger, R. (2017). Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain : A Journal of Neurology, 140(9), 2444-2459.

Glaab, E. (2017) Computational systems biology approaches for Parkinson's disease, Cell and Tissue Research (Special issue Parkinson's disease: Molecules, cells, and circuitries, T. Gasser, H. Braak, K. Del Tredici, Eds.), pp. 1, doi: 10.1007/s00441-017-2734-5

Kolber, P., Stallinger, C., & Krüger, R., (2017). Update zur intensivierten Therapie des fortgeschrittenen idiopathischen Parkinson-Syndroms, Nervenheilkunde, 36(8), pp. 647–654.

Krüger, R., Lingor, P., Doskas, T., Henselmans, J., Danielsen, E. H., de Fabregues, O., Stefani, A., Sensken, S. C., Parra, J. C., Onuk, K., Yegin, A., & Antonini, A. (2017). An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson's Disease Patients. Advances in therapy, 34(7), 1741–1752.

Krüger, R., Klucken, J., Weiss, D., Tönges, L., Kolber, P., Unterecker, S., Lorrain, M., Baas, H., Müller, T., & Riederer, P. (2017). Classification of advanced stages of Parkinson's disease: translation into stratified treatments. Journal of neural transmission (Vienna, Austria : 1996), 124(8), 1015–1027. >> Lesen Sie die Zusammenfassung

Scholten, M., Klemt, J., Heilbronn, M., Plewnia, C., Bloem, B. R., Bunjes, F., Krüger, R., Gharabaghi, A., & Weiss, D. (2017). Effects of Subthalamic and Nigral Stimulation on Gait Kinematics in Parkinson's disease. Frontiers in neurology, 8, 543.

Seidel, K., Bouzrou, M., Heidemann, N., Krüger, R., Schols, L., den Dunnen, W. F. A., Korf, H.-W., & Rub, U. (2017). Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies. Annals of neurology, 81(6), pp. 898-903.

Straniero, L., Rimoldi, V., Samarani, M. et al. (2017). The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p. Sci Rep, 7, 12702.

Trezzi, J., Galozzi, S., Jaeger, C., Barkovits, K., Brockmann, K., Maetzler, W., Berg, D., Marcus, K., Betsou, F., Hiller, K., Mollenhauer, B. (2017) Distinct Metabolomic Signature in Cerebrospinal Fluid in Early Parkinson’s Disease, Movement Disorders,10, pp. 1401, doi: 10.1002/mds.27132

Wang, L., Heckman, M. G., Aasly, J. O., Annesi, G., Bozi, M., Chung, S. J., Clarke, C., Crosiers, D., Eckstein, G., Garraux, G., Hadjigeorgiou, G. M., Hattori, N., Jeon, B., Kim, Y. J., Kubo, M., Lesage, S., Lin, J. J., Lynch, T., Lichtner, P., Mellick, G. D., Mok, V., Morrison, K. E., Quattrone, A., Satake, W., Silburn, P. A., Stefanis, L., Stockton, J. D., Tan, E. K., Toda, T., Brice, A., Van Broeckhoven, C., Uitti, R. J., Wirdefeldt, K., Wszolek, Z., Xiromerisiou, G., Maraganore, D. M., Gasser, T., Krüger, R., Farrer, M. J., Ross, O. A., & Sharma, M. (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of aging, 49, 217.e1-217.e4.


Guebila, M. B., & Thiele, I. (2016). Model-based dietary optimization for late-stage, levodopa-treated, Parkinson’s disease patients. Npj Systems Biology and Applications, 2(1). doi:10.1038/npjsba.2016.13 >> Lesen Sie die Zusammenfassung

Heinzel, S., Roeben, B., Ben-Shlomo, Y., Lerche, S., Alves, G., Barone, P., Behnke, S., Berendse, H. W., Bloem, B. R., Burn, D., Dodel, R., Grosset, D. G., Hu, M., Kasten, M., Krüger, R., Moccia, M., Mollenhauer, B., Oertel, W., Suenkel, U., Walter, U., … Berg, D. (2016). Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned. Frontiers in aging neuroscience, 8, 147.

Krüger, R., Hilker, R., Winkler, C., Lorrain, M., Hahne, M., Redecker, C., Lingor, P., & Jost, W. H. (2016). Advanced stages of PD: interventional therapies and related patient-centered care. Journal of neural transmission (Vienna, Austria : 1996), 123(1), 31–43. >> Lesen Sie die Zusammenfassung

Weiss, D., Herrmann, S., Wang, L., Schulte, C., Brockmann, K., Plewnia, C., Gasser, T., Sharma, M., Gharabaghi, A., Krüger, R. (2016). Alpha-synuclein gene variants may predict neurostimulation outcome. Movement Disorders, 31(4), 601-603. doi:10.1002/mds.26558

Wüst, R., Maurer, B., Hauser, K., Woitalla, D., Sharma, M., & Krüger, R. (2016). Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease. Neurobiology of aging, 39, .


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Lerche, S., Liepelt-Scarfone, I., Alves, G., Barone, P., Behnke, S., Ben-Shlomo, Y., Berendse, H., Burn, D., Dodel, R., Grosset, D., Heinzel, S., Hu, M., Kasten, M., Krüger, R., Maetzler, W., Moccia, M., Mollenhauer, B., Oertel, W., Roeben, B., Sünkel, U., Berg, D. (2015). Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease--Report of the JPND Working Group BioLoC-PD. Neuroepidemiology, 45(4), 282–297.